Anti-aging Activity of Xylaria striata in Drosophila melanogaster
Shi-Jun Yuan
School of Life Science and Engineering, Southwest University of Science and Technology, Mianyang 621010, China.
Wei-Yi Li
School of Life Science and Engineering, Southwest University of Science and Technology, Mianyang 621010, China.
Tian-Tian Jian
School of Life Science and Engineering, Southwest University of Science and Technology, Mianyang 621010, China.
Yi Huang *
School of Life Science and Engineering, Southwest University of Science and Technology, Mianyang 621010, China.
*Author to whom correspondence should be addressed.
Abstract
Aims: To evaluate the application potential of Xylaria striata Pat. in anti-aging field.
Methodology: Extracting the fruit body of X. striata by ultrasonic-assisted extraction method. In this study, Drosophila melanogaster was used as an anti-aging organism material. After feeding with different concentrations of extract, the natural survival time, survival time under oxidative stress and survival time under UV irradiation of D. melanogaster were all measured. In addition, the in vivo activity of SOD、CAT and MAD, protein concentration and body weight were determined to evaluate the anti-aging effect of ethanol extract from X. striata.
Results: The results showed that the ethanol extract of X. striata could extend the lifespan of D. melanogaster under both irradiation and oxidative stress condition. And the ethanol extract could enhance the activity of CAT in D. melanogaster, especially at concentration of 50 μM, and the content of MAD in D. melanogaster were decreased significantly.
Conclusion: This study clarified the anti-aging activity of X. striata in D. melanogaster and it would provide some theoretical basis for its further development and utilization in anti-aging drugs and health food.
Keywords: Xylaria striata, anti-aging, Drosophila melanogaster, lifespan