Influence of Different Families of Commercial Antibiotics on Controlling Nosocomial Infections
Mohamed Abdel-Raouf
Gastroenterology Surgical Center (GEC), Mansoura University, Mansoura, Egypt.
Hisham M. Aldeweik *
Gastroenterology Surgical Center (GEC), Mansoura University, Mansoura, Egypt.
Mohamed S. Albannan
Department of Research and Development, Biotechnology Research Center, Egypt.
Mohamed M. Zaki
Faculty of Science, Port Said University, Port Said, Egypt.
Ahmed E. Abdelkader
Faculty of Science, Port Said University, Port Said, Egypt.
Dalia Moemen
Faculty of Medicine, Mansoura University, Mansoura, Egypt.
*Author to whom correspondence should be addressed.
Abstract
Aims: Nosocomial infection (NI) is one of the most important problems facing the world. This work is dedicated to investigating the prevalence rates of NI in addition to estimating the minimum inhibition concentration (MIC) of commercial antibiotics on isolated bacteria in order to determine the most diluted antibiotic that performed well with more efficiency and minimal toxicity.
Place and Duration of Study: Gastroenterology Surgical Center, Mansoura University, Mansoura, Egypt, between July 2017 and July 2018.
Methodology: This study included 368 different samples (urine, stool, sputum and surgical wounds) from 100 patients A total of 15 commercial antibiotics selected from seven families having different mode of action were used.
Results: Our findings demonstrated that the highest prevalence rate of NI was detected in K. pneumoniae (40%, n=56) followed by MRSA (22.85%, n=32), E. coli (20%, n=28), P. mirabilis (7.85%, n=11), P. putida (5%, n=7) and finally P. aeruginosa (4.3%, n=6). In addition, the results showed variable MICs of various antibiotics on isolated bacteria associated with NI.
Conclusion: Interestingly, our findings showed that quinolones family had the highest impact on all types of isolated bacteria associated with nosocomial infections.
Keywords: Nosocomial infections, antibiotics, K. pneumoniae, MRSA, E. coli, P. mirabilis, P. putida, P. aeruginosa.